Alex Pereira, Diego Lopes open as underdogs for UFC 335

The UFC returns to Las Vegas on December 12 for UFC 335, the promotion's final numbered event of 2026, with three high-profile matchups already confirmed. Charles Oliveira will defend the BMF title against Diego Lopes in the main event, marking Lopes's UFC lightweight debut after competing as a two-time featherweight title challenger. The card also features former two-division champion Alex Pereira facing heavyweight Sergei Pavlovich in the co-main event, with middleweight prospect Joe Pyfer taking on Dana White's Contender Series graduate Bo Nickal.

According to opening betting odds from BetOnline Sports & Casino, Oliveira is favored at -172 against Lopes (+146). Oliveira secured the BMF title with a dominant performance against Max Holloway, while Lopes rebounded from his second loss to Alexander Volkanovski by defeating Steve Garcia in his most recent bout.

In the co-main event, Pavlovich opened as a -130 favorite against Pereira (+111). Pereira is seeking to bounce back after suffering a loss to Ciryl Gane in his UFC heavyweight debut at UFC Freedom 250. Pyfer, meanwhile, is favored at -130 over Nickal (+111) in their middleweight clash.

The card shapes up as a significant event featuring established champions and notable contenders vying for position ahead of the year's conclusion.